The Humane Labs raid is the third heist added to GTA Online in the original 2015 “Heists Update.” It’s got pretty much everything you’d want from a GTA mission — night-vision sequences, an aircraft carrier, fighter jets, a big laboratory shootout.

This guide shows how to maximize both 'Take' and 'Cut' from each and every heist in GTA 5 by choosing the right approach and team members.
Other GTA Guides:

• 100% Completion Guide!
• Beginner's Guide (GTA Online).
• Advanced Nightclub Guide.
• Advanced Guide for MC Business.
• Advanced Smuggler's Run Guide.
• How to Make Easy Money Everyday (Solo Guide).
• Mobile Operations Center (MOC) Guide.
• Guide to Combat Aircraft.
• Import / Export Guide.
• How to Use Mods?
• Terrorbyte Guide.

Recruit Additional Crew Members

Patrick McReary

After the mission 'Complications' you'll unlock the random event 'Getaway Driver' found between Forum Drive and Strawberry Avenue.
Completing the random event by helping the two robbers, Patrick McReary will be unlocked and becomes available as a Gunman for the Heists.
Taliana Martinez

After the mission 'Mr.Philips' you'll unlock the random event 'Crash Rescue' found on the Senora Freeway near the Braddock Pass.
Competing the random event by helping the girl, Taliana Martinez will be unlocked and becomes available as a Driver for the Heists. (If you don't get Taliana to her house in time, she'll bleed out and die, and you'll never be able to unlock her!)

The Jewel Store Job (Smart Approach)

• Max Take: $4,946,153
• Max Michael cut: $1,223,073
• Max Franklin cut: $293,539

• Driver: Karim Denz (8%)
• Gunman: Patrick McReary (12%)
• Hacker: Ricky Lukens (4%)

The 'Smart Approach' is better than the Loud one because only Michael and the Gunman will grab the jewels inside the store. Instead in the 'Loud Approach', the Driver will help too and if you don't get a good Driver, part of the take will be dropped and lost.
So, choose 'Smart Approach', then choose the lowest take Driver because the only thing that will change is that Franklin has to get off the heat using a Bati 801 instead of Sanchez. Choose a good Gunman - Patrick is the best with the lowest take - or your gunman will drop part of the take inside the store and will be killed before reaching the tunnel.
Even if you take the bag from the street when he falls dead, the lower take together with the casualty expenses, will make the worst gunman cost more than a good one.

• Bad Gunman: $4,515,930
• Good Gunman: $4,946,153

As for the Hacker, choose Ricky first of all because he gives you exactly 50 seconds before the alarm starts and 50 seconds is the time given to complete the objective 'Quick Grab' for the Gold medal.

The Merryweather Heist (Any Approach)

• Max Take: $20,000,000
• Max Michael cut: $0
• Max Franklin cut: $0
• Max Trevor cut: $0

In this heist you won't have to choose crew members because the whole job is done by the trio.Also, unfortunately, at the end of the job, whichever approach was chosen, no one gains money.

The Paleto Score

• Max Take: $8,016,020
• Max Michael cut: almost $463,000
• Max Franklin cut: almost $463,000
• Max Trevor cut: almost $463,000

• Gunman: Norm Richards (7%) or Daryl Johns (6%)

The take on this heist depends mainly oh how we move. Each time someone shoots you in the back, you drop money. To avoid that, keep your back covered.
For the team you'll only need one Gunman and if you want to maximize the main characters' cuts, choose either Norm or Daryl. Both will be killed during the mission, but you can grab their bag without any problems. Differently from the Jewel Store Job, the take won't be affected and the casualty expenses are lower than hiring a good gunman - a saving of $18,000 more or less.

The Bureau Raid (Roof Entry Approach)

• Max Take: $331,985
• Max Michael cut: $0
• Max Franklin cut: $242,346

• Hacker: Ricky Lukens (4%)
• Gunman: Daryl Johns (6%), Norm Richards (7%) or Hugh Welsh (7%)
• Driver: Taliana Martinez (5%)

No money for Michael in the Bureau Raid, but Franklin can make a little less than a quarter of a million and to maximize his income, choose the 'Roof Entry' approach.
In the Firefighter approach you'll have two gunmen and if both are mediocre, one will die.
If you hire two good gunmen or two bad gunmen, the cut or the casualty expenses will be higher than by completing the heist with the other approach. Once 'Roof Entry' approach has been chosen, get Ricky as the hacker again( his skills have improved from the previous heist, so he will not cause problems). As your Gunman, choose one guy with the lower cut. He will not die and he'll improve his skill which is best for business.

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Last the Driver, take Taliana so you'll get the best getaway vehicle with the lowest cut. Karim costs more and if you didn't use him in the first heist, he will arrive late at the meet up aboard a Burrito instead of an Ambulance. Obviously if this happens, before reaching Lester, you'll need to shake off the heat.

The Big Score (Obvious Approach)

• Max take: $201,600,000
• Max Michael cut: $41,664,000
• Max Franklin cut: $41,664,000
• Max Trevor cut: $41,664,000

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• Driver 1: Taliana Martinez (5%)
• Driver 2: Karim Denz (8%)
• Gunman 1: D. Jonhs (6%), N. Richards (7%), H. Welsh (7%) or K. Abolaji (8%)
• Gunman 2: D. Jonhs (6%), N. Richards (7%), H. Welsh (7%) or K. Abolaji (8%)

Here we are at the last heist, the Big One. Choose 'Obvious Approach' to maximize your income because you'll need four guys instead of five. But if you like the 'Subtle Approach' more, go on but avoid selecting Karim Denz as first driver - if you haven't used his services in a previous job - because in this case he will get caught by the police before reaching the highway.
So, after selecting the 'Obvious Approach', take Taliana as the first driver (she will pilot first helicopter) and Karim as the second (he will drive the train). Don't do the opposite, especially if Karim is without experience or you'll lose half of the take.
For both Gunmen, select the guys you want, lower their cut, more money you'll take. They won't die or do anything stupid, so don't worry and select guys like Daryl Jonhs (6%), Hugh Welsh (7%), Norm Richards (7%) or Karl Abolaji (8%).

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Confirmation from Rockstar Games

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After releasing a teaser trailer for Grand Theft Auto 5 Online featuring the Diamond Casino and a possible heist, Rockstar Games has confirmed the casino heist is happening.

The new update for GTA 5 Online will go live on Thursday, December 12. It will be available to download on PC, Xbox One, and PS4.

New casino missions

Rockstar Games announced that the upcoming casino missions will be different than previous heists featured in the game. Diamond Casino Heist will be the most lucrative mission ever available in the game.

Diamond Casino Heist will be the most lucrative mission ever available in the game

Players will start fresh, setting up a new business as a front to plan the heist. A retro arcade acts as the front, and it is also where the criminals rehearse their roles for the daring heist.

As the business operates arcade games, players go underground, practicing keypad hacking and opening vault doors. The space stores getaway vehicles and other equipment needed to carry out the heist.

Rockstar Games said: “The Diamond Casino Heist is an all-new approach to Heist architecture and execution: one huge gameplay-packed operation as you work with the Cheng family to infiltrate the most secure building in all of Los Santos.”

Range of opportunities

Players will begin the new mission with prep missions to shape how the heist will go down. There are multiple paths for approach, allowing players to complete the heist one way and replay the mission in a completely different manger.

choices are available inside the casino to keep the heist fresh and exciting

Security measures will constantly be changing regarding the casino. Several choices are available inside the casino to keep the heist fresh and exciting. According to Rockstar Games, outcomes for the player and heist crew can change on the fly. As players deal with a new situation, it leads to more choices during the mission.

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Even the best laid out plans can go awry, with players given the opportunity to keep the mission afloat without fail by shooting their way out with remaining team lives.

Players anxiously waiting

Since the teaser trailer was first released by Rockstar Games on December 4, players have been anxiously waiting for the developer to confirm the heist.

As stated on VSO News, the teaser showed a promo for the Diamond Casino in the game, hacked midway through. Images in the trailer seemingly showed heist plans along with video footage from inside the casino.

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When the casino launched, it did so amid controversy. Concern arose that young people would be influenced by the content, creating a vulnerability to gambling problems in the future.